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KMID : 0370219860300050228
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Yakhak Hoeji
1986 Volume.30 No. 5 p.228 ~ p.231
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Stability of Minoxidil in Aqueous Solution
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Abstract
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The effect of temperature and pH on the degrdation of minoxidil in the aqueous solution was investigated and the stability of pharmaceutical preparation for solution was also studied. The degradation of minoxidil in the aqueous solution was first order type reaction and the rate constant at 20°C in pH 7. 0 phosphate buffer solution was 9. 464 x 10-3 day-i and calculated activation energy was 11.7 kcal/mol. The degradation of minoxidil was acid-base catalytic reaction and the most stable range of pH was about 5.0. The liquid pharmaceutical preparation was very ctahle in 3 months_
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